Application Notes: General

Successful large-scale ion exchange chromatography purification of oligonucleotides provided by BianoGMP GmbH, experts in the productions of therapeutic oligonucleotides

Monitoring of per- and polyfluoroalkyl substances (PFAS) in air is successfully performed by the US EPA using Thermal Desorption-GC/MS.

Novel Thermal Desorption-GC/MS method for determination of formaldehyde using PFPH, automatically loaded onto Tenax TA adsorbent, as derivatization agent.

GERSTEL TD 3.5+ Thermal Desorber successfully passes method VDA278 system performance test for automobile material emissions increasing sample capacity and throughput.

VOCs collected from air onto a sorbent packed tube are released by thermal desorption and focused for GC-MS determination using the novel cryogen free dynamic focusing

Peptides are versatile molecules that have a wide range of applications in biotechnology, medicine, and research. They can be used as drugs, diagnostics, biomarkers, or tools to study cellular processes. However, peptides also pose unique challenges in terms of analysis and purification due to their complexity, diversity, and sensitivity.

Splitless micro-furnace pyrolysis-GC/MS in conjugation with F-Search MPs libraries enable rapid and accurate identification and quantification of trace Microplastics (MPs).

Discover how to accurately analyze purity and impurities, determine sequences, and more with next-generation technologies from Agilent.

This application note describes a method for the rapid and simultaneous quantitation of benzene, 1,4-dioxane, and formaldehyde in personal care products (PCPs). Nine retail hair and skincare products from the United Kingdom were analyzed, with limits of quantitation (LOQs) for benzene in the low-ng g−1 range and 1,4-dioxane and formaldehyde in the sub- and low- μg g−1 range, respectively. Preliminary results indicate that SIFT-MS holds an 8- to 30-fold throughput advantage when compared to conventional gas chromatography (GC-MS).

Inside the Laboratory is a joint series with LCGC and Spectroscopy, profiling analytical scientists and their research groups at universities all over the world. This series spotlights the current chromatographic and spectroscopic research their groups are conducting, and the importance of their research in analytical chemistry and specific industries. In this “Inside the Laboratory –– Women in Separation Science” special edition PDF, we profile four industry leaders and the impact that their research is having in specific fields such as environmental analysis, forensics, national security, and drug development.

Biozen dSEC-7 accurately resolves AAV serotypes 5, 8 and 9 monomer from aggregates in under 10 minutes with consistent results across different mobile phase conditions.

Photodegradation of plastic products is known to accelerate weathering and the resulting release of chemical additives and particles to the environment, however these processes are complex. Here, eight different plastic consumer products were leached in double-distilled water under exposure to strong ultraviolet (UV) light for ten days, and the chemical composition of the leachates was compared to their respective dark controls. The leachates and plastic particles were investigated with a wide battery of chemical-analytical tools to broadly characterize the underlying processes and possible hazards. These covered (a) metal(loid) analysis, (b) microplastic analysis, (c) analysis of >70 organic target analytes and (d) nontargeted screening of the extracts.

We present a reliable NanoPak-C All Carbon SPE method for extracting and detecting 15 OCPs from small quantities of soil (100 mg) and river water (200 µL) samples.

This application note demonstrates the performance of BioCore SEC columns for determining aggregation and fragmentation associated with antibody-based biotherapeutics.

This application note demonstrates a novel composite technology that enhances reproducibility of solid phase extraction compared to a traditional loose packed format.

This app note outlines SPE extraction of water samples following EPA Draft Method 1634, comparing polymeric HLD SPE cartridges and polymeric HLB SPE cartridges.

This application note demonstrates the use of Thermal Desorption as greener approach for sampling of terpenes in air for workplace exposure or terpene profiling

This application note demonstrates the use of Thermal Desorption as a greener approach for sampling of terpenes in the air for workplace exposure or terpene profiling

GC×GC–TOF MS with thermal modulation used to provide detailed and sensitive characterisation of pyrolysis oil composition to identify possible contaminants.

Analysis of VPH in environmental samples by automated flow-modulated headspace–GC×GC–FID, for robust and efficient sample quantitation.

This study investigates the performance of a high-throughput automated thermal desorption instrument coupled to GC–MS/MS for PFAS analysis.

Automated, high-sensitivity analysis of residual fumigants for food safety testing by multi-step enrichment–headspace–trap (MSE–HS–trap) with GC–MS.

Evaluating the effect of storage and packaging on the volatile composition of soft drinks with immersive sorptive extraction & GC×GC–TOF MS.

Analysis of trace per- and polyfluorinated organic vapours in air using cryogen-free thermal desorption and gas chromatography–mass spectrometry.

Microplastics are defined as small plastic particles between 1 µm and 5 mm in size. Due to poor waste management and plastic pollution, they are now documented to be ubiquitous in the environment.1,2 However, pathways of dietary exposure to microplastics are not yet fully understood. The consumption of bottled water has been calculated to increase by 7% annually, with an estimated mean total global consumption of bottled water to be 513 billion liters by 2025. This study demonstrates how the Agilent 8700 Laser Direct Infrared (LDIR) Chemical Imaging System can accurately identify and quantify the presence of microplastics in bottled drinking water. This study also shows the capability of the Agilent Cary 630 FTIR spectrometer to investigate the source of microplastic contamination.

Reports of the omnipresence of microplastics have mainly focused on their presence in the environment, but there is a growing interest in investigating the health impacts of microplastics. Many people would assume that infants' exposure to microplastics would be limited. However, infant formula was found to be a possible exposure pathway. Extracting and isolating microplastics from infant formula can be difficult due to the range of formulations, ingredients, and components, such as fats, proteins, minerals, vitamins, and sugars. This application note demonstrates the importance of quality control in microplastics analysis. The study also shows how the Agilent 8700 Laser Direct Infrared (LDIR) Chemical Imaging System can accurately identify and quantify microplastics in infant formula.

A method to collect and analyse ozone-depleting substances & halogenated greenhouse gases in 100% humidity ambient air with a cryogen-free preconcentration–GC–MS system

This application notes showcases greener HPLC with less solvent using smaller inner diameter columns while maintaining the quality of separation

This application notes showcases greener HPLC with less solvent using smaller inner diameter columns while maintaining the quality of separation

Analyze phthalates 1.4x faster and cut costs by reducing helium consumption 67%.