Welcome to Day 3 of LCGC?s coverage of Pittcon 2011. Today, we present the 2011 LCGC Lifetime Achievement Award as part of our live theater, in booth #3217, at 10:30 a.m.
Welcome to Day 3 of LCGC’s coverage of Pittcon 2011. Today, we present the 2011 LCGC Lifetime Achievement Award as part of our live theater, in booth #3217, at 10:30 am. That presentation and interview will be followed by a full day of programming from ChromAcademy.
The winner of the 2011 LCGC Lifetime Achievement Award is James W. Jorgenson of the University of North Carolina at Chapel Hill. A thought leader in separation science, Jorgenson is well known for his breakthroughs in both capillary electrophoresis and ultrahigh-pressure liquid chromatography. His pioneering work on developed CE as a viable and powerful tool for microscale chemical separations; capillary gel electrophoresis later enabled the sequencing of the human genome. His later work on the use of ultra-high pressures in liquid chromatography, first published in 1997, is widely regarded as critical to the success of what is now known as UHPLC.
Jorgenson also was one of the first to study multidimensional chromatography or multidimensional electrophoresis coupling CE with HPLC, and later interfaced mass spectrometry to CE–HPLC to make a truly 2D hyphenated system. He continues to pursue techniques to greatly increase peak capacity in analytical separations, such as LC-CE, as well as techniques with extreme resolving power, such as flow counterbalanced capillary electrophoresis (FCCE), to solve problems in complex mixture analysis.
Following the Lifetime Achievement Award interview, programming in the LCGC Theater will continue with sessions presented by our partner, ChromAcademy. These will include presentations on future GC technologies and metabolic profiling, and live troubleshooting sessions at 12:15 p.m. and 2:15 p.m.: Bring your questions and problems!
The Complexity of Oligonucleotide Separations
January 9th 2025Peter Pellegrinelli, Applications Specialist at Advanced Materials Technology (AMT) explains the complexity of oligonucleotide separations due to the unique chemical properties of these molecules. Issues such as varying length, sequence complexity, and hydrophilic-hydrophobic characteristics make efficient separations difficult. Separation scientists are addressing these challenges by modifying mobile phase compositions, using varying ion-pairing reagents, and exploring alternative separation modes like HILIC and ion-exchange chromatography. Due to these complexities, AMT has introduced the HALO® OLIGO column, which offers high-resolution, fast separations through its innovative Fused-Core® technology and high pH stability. Alongside explaining the new column, Peter looks to the future of these separations and what is next to come.
Metabolomics Analysis of Low Birth-Weight Infants Using UHPLC-MS/MS Following Lipid Emulsion
January 10th 2025A recent study aimed to directly compare the changes in serum metabolites among very low birth-rate (VLBW) infants following the administration of the soybean oil-based lipid emulsion and soybean oil, medium-chain triglycerides, olive oil, and fish oil (SMOF) lipid emulsion using untargeted metabolomics techniques.
Analyzing New Drug Modalities: An ISC 2024 Interview with Kelly Zhang
January 10th 2025At ISC 2024 in Liverpool, United Kingdom, LCGC International interviewed Kelly Zhang of Genentech about her work analyzing new drug modalities, such as mRNA, oligonucleotides, peptides, and cell and gene therapies.