Welcome to Day 2 of LCGC?s coverage of Pittcon 2011. Today, we present the 2011 Emerging Leader Award as part of our live theater, in booth #3217, at 10:00 a.m.
Welcome to Day 2 of LCGC’s coverage of Pittcon 2011. Today, we present the 2011 Emerging Leader Award as part of our live theater, in booth #3217, at 10:00 a.m. We are also proud to continue our theater program, focusing on hyphenated techniques.
The winner of the 2011 LCGC Emerging Leader award is Dwight R. Stoll, Assistant Professor at Gustavus Adolphus College, in Saint Peter, Minnesota. Stoll has developed fast, comprehensive two‐dimensional high performance liquid chromatography (c2D‐HPLC) as an analytical tool capable of quickly separating and quantifying hundreds of chemical constituents of complex mixtures. Stoll designed and built a 2D-LC instrument that has many unique features and made it possible to do comprehensive 2D-LC with a peak capacity of more than 1000 in 30 min. Such peak capacities have a separating capacity equivalent to several hundred thousand plates in 1D-LC. His laboratory is now working on 3D-HPLC, and has developed systems capable of quantifying compounds at ppb levels in complex matrices with minimal sample preparation and method development for each new analyte-matrix combination encountered.
Following the Emerging Leader interview, our morning theater schedule focuses on hyphenated techniques. At 10:30 a.m., Hernan Cortes of Hernan Cortes Consulting will discuss polymer analysis using multidimensional chromatography combined with mass spectrometry. At 11:00 a.m., Luigi Mondello of the University of Messina will address food sample analysis using comprehensive GCxGC with MS. We will wrap up the morning session with an 11:30 a.m. interview with Sam Yang of the University of Texas at Arlington about LC–MS with online sample preparation to survey metabolites formed in vitro.
We hope you will join us in booth #3217 for these interviews.
The Complexity of Oligonucleotide Separations
January 9th 2025Peter Pellegrinelli, Applications Specialist at Advanced Materials Technology (AMT) explains the complexity of oligonucleotide separations due to the unique chemical properties of these molecules. Issues such as varying length, sequence complexity, and hydrophilic-hydrophobic characteristics make efficient separations difficult. Separation scientists are addressing these challenges by modifying mobile phase compositions, using varying ion-pairing reagents, and exploring alternative separation modes like HILIC and ion-exchange chromatography. Due to these complexities, AMT has introduced the HALO® OLIGO column, which offers high-resolution, fast separations through its innovative Fused-Core® technology and high pH stability. Alongside explaining the new column, Peter looks to the future of these separations and what is next to come.
Metabolomics Analysis of Low Birth-Weight Infants Using UHPLC-MS/MS Following Lipid Emulsion
January 10th 2025A recent study aimed to directly compare the changes in serum metabolites among very low birth-rate (VLBW) infants following the administration of the soybean oil-based lipid emulsion and soybean oil, medium-chain triglycerides, olive oil, and fish oil (SMOF) lipid emulsion using untargeted metabolomics techniques.
Analyzing New Drug Modalities: An ISC 2024 Interview with Kelly Zhang
January 10th 2025At ISC 2024 in Liverpool, United Kingdom, LCGC International interviewed Kelly Zhang of Genentech about her work analyzing new drug modalities, such as mRNA, oligonucleotides, peptides, and cell and gene therapies.