Waters Launches Fit-for-Purpose ACQUITY UPLC H-Class Bio System, the First-of-its-Kind Biocompatible UPLC Platform
New System Advances Macromolecule Analysis through Multiple-Mode Chromatographic Capability, Automated Solvent Blending, and Use of Corrosion Resistant Inert Materials
New System Advances Macromolecule Analysis through Multiple-Mode Chromatographic Capability, Automated Solvent Blending, and Use of Corrosion Resistant Inert Materials
Waters Corporation introduced the first-of-its-kind Waters® ACQUITY UPLC® H-Class Bio System, expanding the scientific and business benefits of UPLC® Technology for macromolecule analysis by optimizing characterization of biomolecule structures supporting their progression to viable biotherapeutics. The new ACQUITY UPLC H-Class Bio System provides the ultimate in large molecule characterization enabling organizations to gather information on the true value of their possible therapeutic products.
Powered by the ACQUITY UPLC H-Class platform with a flow-through-needle sample manager and quaternary solvent manager, the new system performs multiple chromatographic techniques that are needed to characterize complex biomolecules. Additionally, it features an inert flow path, and leverages Waters AutoBlend Plus Technology to optimize the analysis of proteins, peptides, nucleic acids, and glycans.Because of the complexity of any given large molecule, biochemists often must employ one or more chromatographic techniques to accurately separate and characterize any given sample. Powered by proven, reliable and robust UPLC capabilities, the ACQUITY UPLC H-Class Bio System has the flexibility to perform four chromatographic modes on a single system: reversed phase, ion exchange (IEX), size exclusion (SEC), and hydrophilic interaction (HILIC). Scientists can now perform all required assays for robust protein characterization on a single UPLC system.
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The Complexity of Oligonucleotide Separations
January 9th 2025Peter Pellegrinelli, Applications Specialist at Advanced Materials Technology (AMT) explains the complexity of oligonucleotide separations due to the unique chemical properties of these molecules. Issues such as varying length, sequence complexity, and hydrophilic-hydrophobic characteristics make efficient separations difficult. Separation scientists are addressing these challenges by modifying mobile phase compositions, using varying ion-pairing reagents, and exploring alternative separation modes like HILIC and ion-exchange chromatography. Due to these complexities, AMT has introduced the HALO® OLIGO column, which offers high-resolution, fast separations through its innovative Fused-Core® technology and high pH stability. Alongside explaining the new column, Peter looks to the future of these separations and what is next to come.
