Using LC-MS for Next-Gen Biologics: ADCs and Conjugation Chemistry

Deriving antibodies from plasma involves a multi-step process, from plasma collection to antibody purification and quality control, ensuring the final product is safe and effective for therapeutic, diagnostic, or research use. Krish Gosh, PhD, MBA, President of TCG Digital, joined LCGC International to discuss how AI/GenAI applications can optimize several steps to enhance yield, profitability, and process monitoring.

In high-performance liquid chromatography (HPLC), it is common for bases and unreacted ionized silanols on silica-based columns to cause irreproducible retention, broad peaks, and peak tailing when working with basic analytes. David S. Bell, Lead Consultant at ASKkPrime LLC offers innovative HPLC strategies that can help mitigate such issues.

Solid Phase Extraction (SPE) is vital for chromatographic analysis. However, traditional loose-packed SPE products struggle with channelling and inconsistent resin mass, resulting in poor recovery and reproducibility. Discover how innovative composite technology overcomes these challenges to transform sample preparation, ensuring reliable and sensitive chromatographic data.

Raman spectroscopy is the ideal approach to compositional analysis and provides great versatility. In this Q&A, Tom Dearing, Senior Staff Scientist, and John Richmond, Senior Sales Manager, both at Thermo Fisher Scientific, provide an overview of the MarqMetrix All-In-One Process Raman Analyzer.