Tuesday Afternoon Session: Pharmaceutical Analysis
The session titled "Pharmaceutical Analysis" will be chaired by Wolfgang Goetzinger of Amgen Inc. (Cambridge, Massachusetts) and Robert Plumb of Imperial College (London, UK) on Tuesday afternoon in Ballroom A.
The session titled “Pharmaceutical Analysis” will be chaired by Wolfgang Goetzinger of Amgen Inc. (Cambridge, Massachusetts) and Robert Plumb of Imperial College (London, UK) on Tuesday afternoon in Ballroom A.
Klaus Albert of the Institute of Organic Chemistry will start off this session with a presentation titled "Structure Elucidation of Bioactive Compounds Employing Modern Analytical Hyphenated Techniques." The study of bioactive compounds is very popular right now for the development of of pharmaceuticals by industry and academia. This presentation will surely touch upon a lot of the important factors involved with bioactive compounds.
The second presentation in this session will be given by Csaba Horvath Award nominee Volker Neu of the University of Salzburg (Salzburg, Austria) and is titled "High-Speed Liquid Chromatography Hyphenated to High-Resolution Mass Spectrometry in Pharmaceutical Quality Control." Neu's discussion will center around another important issue for the pharmaceutical industry- quality control. This is an area of pharmaceuticals that is always looking for room to grow and improve upon itself.
The third presentation will focus on the detection of impurities in drug formulations. Rudy Sneyers of Johnson and Johnson (Beerse, Belgium) will preesnt "'Safety Net' — Systematic Application of Orthogonal Methods for Automated Detection of New Impurity Compounds in Drug Formulations."
The final presentation in this session will be given by Christopher J. Welch of Merck & Co., Inc. (Rahway, New Jersey) and is titled "New HPLC Technologies in Support of Pharmaceutical Discovery and Development." A fitting end to this session, this topic will touch upon discovery and development in the pharmaceutical industry using HPLC.
The Complexity of Oligonucleotide Separations
January 9th 2025Peter Pellegrinelli, Applications Specialist at Advanced Materials Technology (AMT) explains the complexity of oligonucleotide separations due to the unique chemical properties of these molecules. Issues such as varying length, sequence complexity, and hydrophilic-hydrophobic characteristics make efficient separations difficult. Separation scientists are addressing these challenges by modifying mobile phase compositions, using varying ion-pairing reagents, and exploring alternative separation modes like HILIC and ion-exchange chromatography. Due to these complexities, AMT has introduced the HALO® OLIGO column, which offers high-resolution, fast separations through its innovative Fused-Core® technology and high pH stability. Alongside explaining the new column, Peter looks to the future of these separations and what is next to come.
