Smile MS: Small Molecule Identification Software for Tandem Mass Spectrometry
Get the small molecule analysis you want faster and at a higher confidence level than ever before possible!
Now Available from Wiley!
Get the small molecule analysis you want faster and at a higher confidence level than ever before possible! Thanks to the incredibly robust X-rank algorithm developed by GeneBio and embedded in SmileMS, you can perform a broad, more exact analysis rapidly and confidently. With SmileMS, laboratories can now screen a sample containing globalunknown molecules against one or more LC-MSMS spectral libraries at once and have comprehensive and reliable results making this an extremely powerful method for targeted and unknown screening of small molecules in Clinical and Forensic Toxicology, Doping Control, Food Testing, Metabolomics research and other application fields.
An Easy-To-Use Interface for Routine Analysis and Comprehensive Results
The speed, breadth and accuracy of SmileMS search algorithm sets it apart from other LC-MSMS software. SmileMS is powerful, yet easy to use - accommodating almost any skill level. From a simple two-step approach, designed for novice users and routine technicians, to a more in-depth spectral evaluation process for experts, SmileMS’s intuitive interface makes it easy to get the information you need at the level you want.
Praise for SmileMS:“SmileMS shows good performance for targeted and untargeted indentification. We are therefore able to use SmileMS for librarybased LC-MS screening.” —Dr. Hans Maurer, Department of Experimental and Clinical Toxicology, Saarland University, Germany
SmileMS can be used with any number of libraries, including Wiley-VCH Mass Spectra of Design Drugs 2011, AB SCIEX, NIST, and the new Wiley Registry of Tandem Mass Spectral Data. Call now to arrange your 21 Day Free Trial 800.245.6217 or email dbinquiry@wiley.com
The Complexity of Oligonucleotide Separations
January 9th 2025Peter Pellegrinelli, Applications Specialist at Advanced Materials Technology (AMT) explains the complexity of oligonucleotide separations due to the unique chemical properties of these molecules. Issues such as varying length, sequence complexity, and hydrophilic-hydrophobic characteristics make efficient separations difficult. Separation scientists are addressing these challenges by modifying mobile phase compositions, using varying ion-pairing reagents, and exploring alternative separation modes like HILIC and ion-exchange chromatography. Due to these complexities, AMT has introduced the HALO® OLIGO column, which offers high-resolution, fast separations through its innovative Fused-Core® technology and high pH stability. Alongside explaining the new column, Peter looks to the future of these separations and what is next to come.
Metabolomics Analysis of Low Birth-Weight Infants Using UHPLC-MS/MS Following Lipid Emulsion
January 10th 2025A recent study aimed to directly compare the changes in serum metabolites among very low birth-rate (VLBW) infants following the administration of the soybean oil-based lipid emulsion and soybean oil, medium-chain triglycerides, olive oil, and fish oil (SMOF) lipid emulsion using untargeted metabolomics techniques.
Analyzing New Drug Modalities: An ISC 2024 Interview with Kelly Zhang
January 10th 2025At ISC 2024 in Liverpool, United Kingdom, LCGC International interviewed Kelly Zhang of Genentech about her work analyzing new drug modalities, such as mRNA, oligonucleotides, peptides, and cell and gene therapies.
