Simplifying Nano-Separations for Proteomics
Thermo Product Profile
Chromatographic Excellence at Nano-Scale: Research into critical disease areas, such as cancer and autoimmunity, increasingly focuses on biomarker discovery and advanced proteomics. Central to this research is reliable, dependable separations technology. The Thermo Scientific EASY-Column nano-flow LC columns are packed with the highest purity chromatographic silica, guaranteed to be fully biocompatible and metal free. The EASY-Column™ is a capillary column, designed with a focus on simplicity and strict quality control.
Simple Flexible Design: Compatible with virtually any nano LC system, including the Thermo Scientific EASY-nLCII Nano-LC, the EASY-Column is ideally optimized for use in online LC-MS. One nano-LC column, with two connector kit options for easy and reproducible connections, the EASY-Column will simplify your nano-LC applications.
Quality Control on Every Column: The EASY-Column is manufactured under the most stringent quality control protocols, with rigorous testing carried-out on every single column. The precision cutting and polishing of the column ends and secure connections, ensure that this column has zero dead volume. The EASY-Column provides consistent, reproducible analyte peaks with the minimum peak width and maximum peptide sequence coverage.
For more information on the Thermo Scientific EASY-Column, visit www.thermoscientific.com/easycolumn today!
The Complexity of Oligonucleotide Separations
January 9th 2025Peter Pellegrinelli, Applications Specialist at Advanced Materials Technology (AMT) explains the complexity of oligonucleotide separations due to the unique chemical properties of these molecules. Issues such as varying length, sequence complexity, and hydrophilic-hydrophobic characteristics make efficient separations difficult. Separation scientists are addressing these challenges by modifying mobile phase compositions, using varying ion-pairing reagents, and exploring alternative separation modes like HILIC and ion-exchange chromatography. Due to these complexities, AMT has introduced the HALO® OLIGO column, which offers high-resolution, fast separations through its innovative Fused-Core® technology and high pH stability. Alongside explaining the new column, Peter looks to the future of these separations and what is next to come.
Metabolomics Analysis of Low Birth-Weight Infants Using UHPLC-MS/MS Following Lipid Emulsion
January 10th 2025A recent study aimed to directly compare the changes in serum metabolites among very low birth-rate (VLBW) infants following the administration of the soybean oil-based lipid emulsion and soybean oil, medium-chain triglycerides, olive oil, and fish oil (SMOF) lipid emulsion using untargeted metabolomics techniques.
Analyzing New Drug Modalities: An ISC 2024 Interview with Kelly Zhang
January 10th 2025At ISC 2024 in Liverpool, United Kingdom, LCGC International interviewed Kelly Zhang of Genentech about her work analyzing new drug modalities, such as mRNA, oligonucleotides, peptides, and cell and gene therapies.
