Session 730: LC–MS—General Interest

Session 730
Room W176b, 1:30 pm

March 6 - Chicago, Illinois - This Monday afternoon session will be presided over by Eduard Rogatsky of the Wadsworth Center, DEHS.

The session will begin with a presentation by Eduard Rogatsky of the New York State Department of Health who will present “Development of High Throughput LC–MS/MS Method for Analysis of Perfluorooctanoic Acid from Serum, Suitable for Large-Scale Human Bio-Monitoring. Rogatsky’s presentation will focus on a simple method using a high-throughput sample preparation approach that should be advantageous for large-scale epidemiological or biomonitoring studies.

Following Rogatsky, Lei Cheng of Nalco Champion, an Ecolab Company, will present “Differentiation and Quantitation of Phosphonates Using Ion Chromatography and Triple Quadrupole Mass Spectrometry.” Cheng will discuss the development of a high sensitive and specific quantitation method for phosphates in an aqueous matrix by ion chromatography and triple-quadrupole mass spectrometry.

Robin Hendrikus Johannes Kemperman of the University of Florida will speak next on “Clinical Isomer Analysis in Blood Plasma with Ion Mobility–Mass Spectrometry.” This presentation will review several strategies that were developed to improve the ion mobility spectrometry separation of metabolites in blood plasma, with the goal of significantly reduced analysis time.

Yun Chen will follow Kemperman’s presentation with a “Quantitative Study of microRNAs by Immobilized DNA-Peptide Probe and Liquid Chromatography–Tandem Mass Spectrometry-Based Quasi-Targeted Proteomics.” Chen’s discussion will focus on the development of an LC–MS/MS-based quasi-targeted proteomics assay.

After a short recess, Yanhui Wang of the Ohio State University will give a talk on the “Separation of Metal Nanoparticles by Ultrathin Layer Chromatography Using Electrospun Nanofibers as the Stationary Phase.” The analytical performance of this method will be evaluated under optimized conditions.

Jason Kieltyka of Abbott Laboratories will speak next on “Sample Collection Tubes-A Preanalytical Factor that Can Influence Laboratory Developed In Vitro Diagnostic Tests.” Kieltyka will discuss the results of a customer comment that aliquot tubes from a specific source received unusual results from an LC–MS/MS laboratory developed test for 25OHD2/3.

Aviv Amirav from Tel Aviv University will follow with a presentation titled “LC–MS with Cold EI-The New System and Recent Applications.” The presentation will include a discussion about the development of a new electron ionization (EI) LC–MS system with cold EI based on an Agilent 5977 GC–MS system.

The final presentation will be given by Sonia Medina of Corporación Universitaria Lasallista. The presentation, titled “Agro-Industrial Residues from Physalis peruviana Calcyces as Natural Source of Phytoprostanes and Phenolic Compounds,” will focus on a study that has allowed increasing knowledge about the chemical composition of calyces of the Cape gooseberry or goldenberry and how it could support the valorization of a class of agro-industries residues.