Thermo Product Profile
High quality sample preparation is fundamental in obtaining sensitive and accurate chromatographic separations. The new Thermo Scientific HyperSep SPE Applications Notebook provides you with a 144 page reference guide, which includes technical specifications and protocols to assist you in selecting an appropriate Solid Phase Extraction (SPE) solution for your needs. SPE is one technique for processing samples to concentrate the analyte, remove interfering compounds and transfer the analyte into a solvent more suitable for analysis. Covering the SPE requirements of a broad range of industries and laboratories this Applications Notebook contains pharmaceutical, environmental, forensic and food safety applications.
SPE provides significant advantages over alternative methods; the simplicity of the process and efficiency of extraction giving superior recoveries and sample processing times. The HyperSep SPE Applications Notebook contains information to guide you in selecting the appropriate SPE phase by considering:
Download the Thermo Scientific HyperSep SPE Applications Notebook at www.thermoscientific.com/SPE to see how you can enhance your sample preparation.
The Complexity of Oligonucleotide Separations
January 9th 2025Peter Pellegrinelli, Applications Specialist at Advanced Materials Technology (AMT) explains the complexity of oligonucleotide separations due to the unique chemical properties of these molecules. Issues such as varying length, sequence complexity, and hydrophilic-hydrophobic characteristics make efficient separations difficult. Separation scientists are addressing these challenges by modifying mobile phase compositions, using varying ion-pairing reagents, and exploring alternative separation modes like HILIC and ion-exchange chromatography. Due to these complexities, AMT has introduced the HALO® OLIGO column, which offers high-resolution, fast separations through its innovative Fused-Core® technology and high pH stability. Alongside explaining the new column, Peter looks to the future of these separations and what is next to come.
Metabolomics Analysis of Low Birth-Weight Infants Using UHPLC-MS/MS Following Lipid Emulsion
January 10th 2025A recent study aimed to directly compare the changes in serum metabolites among very low birth-rate (VLBW) infants following the administration of the soybean oil-based lipid emulsion and soybean oil, medium-chain triglycerides, olive oil, and fish oil (SMOF) lipid emulsion using untargeted metabolomics techniques.
Analyzing New Drug Modalities: An ISC 2024 Interview with Kelly Zhang
January 10th 2025At ISC 2024 in Liverpool, United Kingdom, LCGC International interviewed Kelly Zhang of Genentech about her work analyzing new drug modalities, such as mRNA, oligonucleotides, peptides, and cell and gene therapies.