Pushing the Limits of Small Molecule Structural Characterization with High-Resolution Ion Mobility (HRIM)

Confronted with the complexities of your samples? Learn about new game-changing analytical technology for small molecules and drugs powered by the MOBIE system. With superior resolution, enhanced throughput, and unmatched reproducibility—this is not the ion mobiltity you are used to.

Register Free: https://www.chromatographyonline.com/lcgc_w/high-resolution

Event Overview:

Ion mobility-mass spectrometry (IM-MS) has emerged as a powerful analytical technique for qualitative and quantitative analysis of small molecules including drugs. Recent technological advances, such as the development of Structures for Lossless Ion Manipulations (SLIM) high-resolution ion mobility (HRIM), have significantly progressed structural characterization capabilities while also offering substantial improvement in throughput due to the rapid nature of the gas-phase separations. This presentation will highlight recent developments in HRIM applications to a range of biologically, clinically, and pharmaceutically relevant small molecules including new psychoactive substances like fentanyl analogs and synthetic cannabinoids. A special emphasis will be on differentiation and identification of isomeric species (i.e., stereoisomers, prototropic isomers, atropisomers, etc.).

Key Learning Objectives:

• Advantages of ion mobility-mass spectrometry (IM-MS) for analysis of small molecules
• Implementation of IM with existing analytical methods (i.e., LC-MS workflows)
• Benefits of high-resolution IM techniques for rapid structural characterization of drug isomers
  

Who Should Attend:

• Principal Investigator
• Lab Director
• Scientist
• Core Facility Director
• Post Doc

Speaker:

Christopher Chouinard
Assistant Professor
Clemson University

Dr. Christopher Chouinard received his Ph.D. from the University of Florida and did post-doctoral training at Pacific Northwest National Laboratory (PNNL). He has been an Assistant Professor at Clemson University since 2022, and his group develops ion mobility-mass spectrometry (IM-MS) methods and technology for a variety of bioanalytical applications.

Register Free:
https://www.chromatographyonline.com/lcgc_w/high-resolution