Pegasus 4D GCxGC-TOFMS
LECO product profile
Routine Pegasus® 4D GCxGC-TOFMS optimisation is now even easier. Variable Modulation Times (VMT) feature was designed and implemented into LECO’s ChromaTOF® single software platform for even more flexibility. Traditional GCxGC uses a fixed modulation period and can result in an analytical compromise to the 1st dimension separation. The advantage of VMT enables the operator to specify at the click of a button their own and different modulation times throughout the GCxGC run. Typically, applications benefiting from GCxGC separations are matrix heavy &/or are complex samples containing a broad range of analytes. In such complex mixtures, early eluting and more volatile analytes actually require shorter modulation times whilst later eluting analytes (high boilers) require much longer modulation times. Using the new LECO VMT programming style results in graduated Pegasus 4D® GCxGC-TOFMS chromatograms in the 2nd dimension and so preserves the valuable separation in the first dimension. This feature maximizes resolution in both the first and second dimensions and is compatible with LECO’s traditional LN2 and Consumable Free (CF) Pegasus 4D® GCxGC-TOFMS instruments.
Join the experts in the field who routinely operate the Pegasus 4D® GCxGC-TOFMS and learn from their experiences. The 2nd European GCxGC Symposium takes place 20th & 21st September, University Regensburg, Germany. Registration is open, for more information contact the LECO Separation Science team.
Marie-Bernays-Ring 31
41199 Mönchengladbach
Germany
Tel: +49 (0)2166 687 -104 or -107
Email: SepSci@leco.de
Web address www.leco.com & www.leco-etc.com
An LC–HRMS Method for Separation and Identification of Hemoglobin Variant Subunits
March 6th 2025Researchers from Stanford University’s School of Medicine and Stanford Health Care report the development of a liquid chromatography high-resolution mass spectrometry (LC–HRMS) method for identifying hemoglobin (Hb) variants. The method can effectively separate several pairs of normal and variant Hb subunits with mass shifts of less than 1 Da and accurately identify them in intact-protein and top-down analyses.
The Next Frontier for Mass Spectrometry: Maximizing Ion Utilization
January 20th 2025In this podcast, Daniel DeBord, CTO of MOBILion Systems, describes a new high resolution mass spectrometry approach that promises to increase speed and sensitivity in omics applications. MOBILion recently introduced the PAMAF mode of operation, which stands for parallel accumulation with mobility aligned fragmentation. It substantially increases the fraction of ions used for mass spectrometry analysis by replacing the functionality of the quadrupole with high resolution ion mobility. Listen to learn more about this exciting new development.
