New Agilent 6550 iFunnel Q-TOF LC/MS System
Agilent product profile
The Agilent 6550 iFunnel Q-TOF LC/MS System incorporates the revolutionary Agilent iFunnel technology delivering the lowest detection levels of any high resolution LC/MS instrument. For the first time ever, you can be confident in achieving low femtogram-level sensitivity with high resolution and accurate mass - making it the ideal choice for pharmaceutical, metabolite ID, discovery proteomics, metabolomics, food safety, forensics, toxicology, and environmental screening applications.
iFunnel increases ion transfer to achieve the lowest detection levels of any high resolution LC/MS instrument, achieving low femtogram-level sensitivity
Ion Beam Compression and Shaping (IBCS) technology provides the greatest sensitivity while maintaining 40k mass resolution, sub ppm mass accuracy, and a faster scan rate up to 50 spectra per second.
Agilent Jet Stream technology combined with improved ion optics provide 5x greater on-column sensitivity and increase up time to maintain the highest sensitivity for high throughput applications.
In-spectrum dynamic range of up to 5 orders of magnitude reveals trace-level targets, even in the presence of much more abundant compounds
MassHunter Workstation software takes advantage of accurate mass MS and MS/MS and high definition isotopic data to facilitate profiling, characterization, identification and quantification of compounds in complex mixtures.
To learn more about the Agilent 6550 iFunnel Q-TOF LC/MS System, click here.
The Complexity of Oligonucleotide Separations
January 9th 2025Peter Pellegrinelli, Applications Specialist at Advanced Materials Technology (AMT) explains the complexity of oligonucleotide separations due to the unique chemical properties of these molecules. Issues such as varying length, sequence complexity, and hydrophilic-hydrophobic characteristics make efficient separations difficult. Separation scientists are addressing these challenges by modifying mobile phase compositions, using varying ion-pairing reagents, and exploring alternative separation modes like HILIC and ion-exchange chromatography. Due to these complexities, AMT has introduced the HALO® OLIGO column, which offers high-resolution, fast separations through its innovative Fused-Core® technology and high pH stability. Alongside explaining the new column, Peter looks to the future of these separations and what is next to come.
Metabolomics Analysis of Low Birth-Weight Infants Using UHPLC-MS/MS Following Lipid Emulsion
January 10th 2025A recent study aimed to directly compare the changes in serum metabolites among very low birth-rate (VLBW) infants following the administration of the soybean oil-based lipid emulsion and soybean oil, medium-chain triglycerides, olive oil, and fish oil (SMOF) lipid emulsion using untargeted metabolomics techniques.
Analyzing New Drug Modalities: An ISC 2024 Interview with Kelly Zhang
January 10th 2025At ISC 2024 in Liverpool, United Kingdom, LCGC International interviewed Kelly Zhang of Genentech about her work analyzing new drug modalities, such as mRNA, oligonucleotides, peptides, and cell and gene therapies.
