MS of Polymers/Materials II: HPLC and Ion Mobility Separation
Wednesday afternoon's session titled "MS of Polymers/Materials II: HPLC and Ion Mobility Separation" is part II of Wednesday morning session, "MS of Polymers/Materials I: Structures and Properties." The second half of this session will pick up where part one left off and address additional topics involving HPLC and other applications.
Wednesday afternoon's session titled "MS of Polymers/Materials II: HPLC and Ion Mobility Separation" is part II of Wednesday morning session, "MS of Polymers/Materials I: Structures and Properties." The second half of this session will pick up where part one left off and address additional topics involving HPLC and other applications.
The first presentation in this session will be given by Mark Arnould of Xerox titled, "Polymer Analysis using GPC, Thermospray Deposition and MALDI-ToF Mass Spectrometry," and will begin at 2:30 PM. Arnould is planning to discuss novel Instrumentation and "high-throughput" sample preparation.
The second presentation, scheduled to begin at 2:50PM, will be given by Nilufer Solak and Chrys Wesdemiotis of The University of Akron (Akron, OH). The tallk, "Structural Characterization of a Complex Nonionic Surfactant by LC-MSn" will address the complete structural analysis of a multicomponent industrial surfactant, Tween 85 (polyoxyethylene sorbitan trioleate), by reverse phase LC-MSn.
Following up that presentation is another one at 3:10Pm titled, "Characterization on Poly (n-Butyl Acrylate)s by LC/ESI-MSn," and presented by Junkan Song 1, Jan W. van Velde1, Luc L.T. Vertommen1, Ron M.A. Heeren2, and Oscar F. van den Brink1 of1Research, Development and Innovation, AkzoNobel and 2FOM Inst. Atomic/Molecular Phy. Their presentation will discuss the structure elucidation of isomers in acrylate polymers and insight in polymerization mechanisms by high accuracy LC/MSn.
"Recent Mass Spectrometric Developments and Investigations for Age Determination of Ball Point Ink Entries on Paper," presented by Dieter Kirsch1, Vincent Guillou1, Bernhard Spengler2, Peter Seiler1, and Fritz Koehler1 of 1Bundeskriminalamt and 2Analytical Chemistry is next on the agenda. This talk will present two new mass spectrometric approaches for the examination of the authenticity of documents based on different substance classes.
The second to last discussion in this session, "Identification of Poly(p-phenylene terephthalamide) Branching and Metathesis Products," will be given by Anthony P. Gies and David M. Hercules of Vanderbilt University, (Nashville, TN). Their presentation will address a first report of arylamide metathesis reactions, NMP side reactions leading to PPD-T end group modification, and PPD-T branching.
Last, but not least, will be a presentation on "Ion Mobility Spectrometry-Mass Spectrometry of Star-branched poly(ethylene glycols)," byBarbara S. Larsen2, Calvin A. Austin1, Brian Bohrer3, Ellen D. Inutan1, Sadish Karunaweera1, David E. Clemmer3, and Sarah Trimpin1 from 1Wayne State University (Detroit, MI), 2The DuPont Company, and 3Indiana University (Bloomington, IN). Their presentation will close-out this session with the discussion of IMS-MS cleanly separated star-branched isomeric composition of respective chain lengths variations and from the linear polymer in mixture analysis.
AI and GenAI Applications to Help Optimize Purification and Yield of Antibodies From Plasma
October 31st 2024Deriving antibodies from plasma products involves several steps, typically starting from the collection of plasma and ending with the purification of the desired antibodies. These are: plasma collection; plasma pooling; fractionation; antibody purification; concentration and formulation; quality control; and packaging and storage. This process results in a purified antibody product that can be used for therapeutic purposes, diagnostic tests, or research. Each step is critical to ensure the safety, efficacy, and quality of the final product. Applications of AI/GenAI in many of these steps can significantly help in the optimization of purification and yield of the desired antibodies. Some specific use-cases are: selecting and optimizing plasma units for optimized plasma pooling; GenAI solution for enterprise search on internal knowledge portal; analysing and optimizing production batch profitability, inventory, yields; monitoring production batch key performance indicators for outlier identification; monitoring production equipment to predict maintenance events; and reducing quality control laboratory testing turnaround time.
