More information through an extra dimension in peak separations
Good news for users analyzing complex sample mixtures: Shimadzu offers an extra dimension in peak separations for all hyphenation technologies in chromatography
Good news for users analyzing complex sample mixtures: Shimadzu offers an extra dimension in peak separations for all hyphenation technologies in chromatography - no matter whether Heart-Cut MDGC, comprehensive GCxGC(qMS), LCxGC(qMS) or LCxLC(MS) analysis. Users obtain additional and more precise qualitative and quantitative information on the compounds of interest.
This breakthrough solution enables in-depth insights by Shimadzu´s unique MDGC Heart-Cut Technology transferring selected unresolved peaks into the second column. Multiple cut times are set by mouse clicks and stored in the method of MDGCsolution software. Comprehensive multidimensional technologies provide highest peak capacity, combined perfectly with the fastest quadrupole MS speed technologies marketwide. A user-friendly hardware design and instructive unique software for comprehensive qualitative and quantitative data analysis give the breakthrough in these technologies.
For more information please visit ref="http://www.shimadzu.eu">www.shimadzu.eu
The Complexity of Oligonucleotide Separations
January 9th 2025Peter Pellegrinelli, Applications Specialist at Advanced Materials Technology (AMT) explains the complexity of oligonucleotide separations due to the unique chemical properties of these molecules. Issues such as varying length, sequence complexity, and hydrophilic-hydrophobic characteristics make efficient separations difficult. Separation scientists are addressing these challenges by modifying mobile phase compositions, using varying ion-pairing reagents, and exploring alternative separation modes like HILIC and ion-exchange chromatography. Due to these complexities, AMT has introduced the HALO® OLIGO column, which offers high-resolution, fast separations through its innovative Fused-Core® technology and high pH stability. Alongside explaining the new column, Peter looks to the future of these separations and what is next to come.
Metabolomics Analysis of Low Birth-Weight Infants Using UHPLC-MS/MS Following Lipid Emulsion
January 10th 2025A recent study aimed to directly compare the changes in serum metabolites among very low birth-rate (VLBW) infants following the administration of the soybean oil-based lipid emulsion and soybean oil, medium-chain triglycerides, olive oil, and fish oil (SMOF) lipid emulsion using untargeted metabolomics techniques.
Analyzing New Drug Modalities: An ISC 2024 Interview with Kelly Zhang
January 10th 2025At ISC 2024 in Liverpool, United Kingdom, LCGC International interviewed Kelly Zhang of Genentech about her work analyzing new drug modalities, such as mRNA, oligonucleotides, peptides, and cell and gene therapies.
