Monday Tutorial Sessions
The tutorial sessions at HPLC 2018 are part of the conference’s educational mission. The sessions consist of presentations given by experts on various topics, with more background provided than might be presented in a typical 20-minute talk.
The tutorial sessions at HPLC 2018 are part of the conference’s educational mission. The sessions consist of presentations given by experts on various topics, with more background provided than might be presented in a typical 20-minute talk. The goal of these free sessions is to make the topics more accessible to less-experienced users. In some cases, discussion and other interactive activities may be incorporated into the session. The sessions are open to all conferees, with seating available on a first-come basis.
Monday’s 45-minute tutorial sessions cover topics ranging from challenges for separation science and mass spectrometry in the characterization of biotherapeutic proteins to the use of monolithic LC columns.
The first session (Session 2D) will be presented at 8:55 a.m. by Christian G. Huber of the University of Salzburg and is titled “Molecular Characterization of Biotherapeutic Proteins: Concepts and Challenges for Separation Science and Mass Spectrometry.”
The second session (Session 3D), titled “Analytical Challenges in the Development and Implementation of Continuous Manufacturing Processes,” will be presented by Todd Maloney of Eli Lilly and Company. The session will begin at 11:15 a.m.
The third session (Session 4D), “Chiral Separations,” is scheduled to begin at 1:55 pm. It will be presented by Christopher J. Welch of the Indiana Consortium for Analytical Science and Engineering.
The final tutorial session of the day (Session 5D) will begin at 4:55 pm and is titled “Prospects of Monolithic Columns for LC in the Era of Sub 2-Micrometer Particles.” This session will be presented by Frantisek Svec of Charles University.
Measuring Stress and Reproductive Hormones in Dolphins with UPLC
November 25th 2024A recent study measured stress and reproductive hormones in three stocks of free-ranging bottlenose dolphins inhabiting different natural salinities across the Gulf of Mexico, with hormones extracted from the blubber of 82 remotely biopsied dolphins and quantified using ultra performance liquid chromatography (UPLC) coupled with orbitrap fusion mass spectrometry.
AI and GenAI Applications to Help Optimize Purification and Yield of Antibodies From Plasma
October 31st 2024Deriving antibodies from plasma products involves several steps, typically starting from the collection of plasma and ending with the purification of the desired antibodies. These are: plasma collection; plasma pooling; fractionation; antibody purification; concentration and formulation; quality control; and packaging and storage. This process results in a purified antibody product that can be used for therapeutic purposes, diagnostic tests, or research. Each step is critical to ensure the safety, efficacy, and quality of the final product. Applications of AI/GenAI in many of these steps can significantly help in the optimization of purification and yield of the desired antibodies. Some specific use-cases are: selecting and optimizing plasma units for optimized plasma pooling; GenAI solution for enterprise search on internal knowledge portal; analysing and optimizing production batch profitability, inventory, yields; monitoring production batch key performance indicators for outlier identification; monitoring production equipment to predict maintenance events; and reducing quality control laboratory testing turnaround time.
