This session includes presentations of studies performed using mass spectrometry imaging techniques ranging from matrix-assisted laser desorption-ionization (MALDI) MS imaging to rapid evaporative ionization MS (REIMS) for applications such as 3D assessment of tumors, acquiring information about metabolic pathways of diabetes, and examination of metabolic exchange in bacteria.
Ballroom ACE
This session includes presentations of studies performed using mass spectrometry imaging techniques ranging from matrix-assisted laser desorption-ionization (MALDI) MS imaging to rapid evaporative ionization MS (REIMS) for applications such as 3D assessment of tumors, acquiring information about metabolic pathways of diabetes, and examination of metabolic exchange in bacteria.
The first presentation in the session will be given by Pierre Chaurand of the University of Montreal (Montreal, Canada) and is titled “Imaging Mass Spectrometry: Current Performance and Upcoming Challenges.” Chaurand will present an overview of the development of imaging MS and discuss the state of the art of the technology, including sample preparation, instrumentation, and data analysis.
The next talk, to be delivered by Erin H. Seeley of Vanderbilt University (Nashville, Tennessee) is titled “Correlation of MS, MRI, and Optical Images for 3D Assessment of the Tumor Microenvironment” and will discuss the use of the different techniques to examine the anti-tumor activity of an antibody in human breast cancer cells in immunocompromised mice.
Pieter Dorrestein of the University of California, San Diego, Skaggs School (La Jolla, California) will present the next talk, “Revealing Bacterial Post-Translationally Modified Cannibalistic Metabolic Exchange Factors with Imaging Mass Spectrometry.” Dorrestein’s presentation will discuss the use of imaging mass spectrometry of bacteria cultured on a MALDI plate.
The fourth presentation in the session, “More Information in Less Time: Strategies for High Spatial and High Mass Spectral Resolution Imaging Utilizing a Hybrid LIT-Orbitrap MS,” will be delivered by David C. Perdian of Iowa State University, Ames Laboratory US DOE (Ames, Iowa). The presentation will discuss imaging MS data acquisition strategies that scan both the linear ion trap and orbitrap mass analyzers in tandem to acquire information and minimize data acquisition time.
The penultimate presentation will be given by Raf Van de Plas of K.U. Leuven – SCD-SISTA Bioinformatics and K.U. Leuven – ProMeta Core Facility (Leuven, Belgium) and is titled “Going Beyond Images: Exploration of Hormone Processing Pathways in Diabetic Mouse Models via Mass Spectral Imaging and Data-Mining.” According to the authors, the data-mining method provides diabetes metabolic pathway screening directly from tissue and surpasses standard molecular imaging uses of MS imaging.
Finally, Zoltan Takats of the Justus-Liebig-University (Giessen, Germany) will present “Intraoperative Identification of Malignant Gastrointestinal Tumors and Proximal Metastases by Rapid Evaporative Ionization Mass Spectrometry.” This presentation will discuss the use of the technique to analyze ions formed during electrosurgical dissection in a surgical environment.
This information is supplementary to the article “Accelerating Monoclonal Antibody Quality Control: The Role of LC–MS in Upstream Bioprocessing”, which was published in the May 2025 issue of Current Trends in Mass Spectrometry.
Investigating the Protective Effects of Frankincense Oil on Wound Healing with GC–MS
April 2nd 2025Frankincense essential oil is known for its anti-inflammatory, antioxidant, and therapeutic properties. A recent study investigated the protective effects of the oil in an excision wound model in rats, focusing on oxidative stress reduction, inflammatory cytokine modulation, and caspase-3 regulation; chemical composition of the oil was analyzed using gas chromatography–mass spectrometry (GC–MS).
Evaluating Natural Preservatives for Meat Products with Gas and Liquid Chromatography
April 1st 2025A study in Food Science & Nutrition evaluated the antioxidant and preservative effects of Epilobium angustifolium extract on beef burgers, finding that the extract influenced physicochemical properties, color stability, and lipid oxidation, with higher concentrations showing a prooxidant effect.