MALDI imaging
MALDI imaging is a technique that allows the direct visualization of drugs and metabolites in tissue.
Visualize the distribution of drugs and metabolites in tissue without the time and expense of radiolabels or molecular tags!
MALDI imaging is a technique that allows the direct visualization of drugs and metabolites in tissue. One of the latest developments in this field is the seamless integration of MALDI imaging and virtual microscopy to provide detailed histopharmacology.
Because MALDI imaging uses mass spectrometry to detect targets, the distribution of each unique molecular formula can be monitored separately. The power of MALDI imaging combined with histology MALDI can help answer important questions such as:
See examples from real life DMPK research in this review article:
Castellino S, Groseclose MR, Wagner D (2011), MALDI imaging mass spectrometry: bridging biology and chemistry in drug development. Bioanalysis. 3(21):2427-41 http://www.future-science.com/doi/abs/10.4155/bio.11.232
See here a real-time demonstration of how histology and MALDI drug imaging are integrated in an easy and intuitive way: http://www.youtube.com/watch?v=eyyAIFHlrg0
Click here for more information about MALDI Imaging!
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A Matrix-Matched Semiquantification Method for PFAS in AFFF-Contaminated Soil
Published: April 14th 2025 | Updated: April 14th 2025Catharina Capitaine and Melanie Schüßler from the Faculty of Geosciences at the University of Tübingen, Tübingen, Germany describe a novel approach using matrix-matched semiquantification to investigate per- and polyfluoroalkyl substances (PFAS) in contaminated soil.
