LC-MS Study Shows Reliable way to Measure Leukemia Markers
A study led by cancer researchers at Ohio State University's Comprehensive Cancer Center's Experimental Therapeutics Program.has validated a method for reliably measuring variations in certain proteins that may make good biomarkers in chronic leukemia patients.
A study led by cancer researchers at Ohio State University's Comprehensive Cancer Center's Experimental Therapeutics Program.has validated a method for reliably measuring variations in certain proteins that may make good biomarkers in chronic leukemia patients. The study shows that LC-MS can measure variations in histones. The technology accurately detected differences in the composition of histones in chronic lymphocytic leukemia (CLL) cells compared with their healthy counterparts- B lymphocytes. These variations are a promising molecular biomarker that might improve the diagnosis and gauge response to therapy in CLL patients.
LCGC’s Year in Review: Highlights in Liquid Chromatography
December 20th 2024This collection of technical articles, interviews, and news pieces delves into the latest innovations in LC methods, including advance in high performance liquid chromatography (HPLC), ultrahigh-pressure liquid chromatography (UHPLC), liquid chromatography–mass spectrometry (LC–MS), and multidimensional LC.
Next Generation Peak Fitting for Separations
December 11th 2024Separation scientists frequently encounter critical pairs that are difficult to separate in a complex mixture. To save time and expensive solvents, an effective alternative to conventional screening protocols or mathematical peak width reduction is called iterative curve fitting.
Mobile Phase Buffers in Liquid Chromatography: A Review of Essential Ideas
December 11th 2024In this installment of "LC Troubleshooting," Dwight Stoll discusses several essential principles related to when and why buffers are important, as well as practical factors, such as commonly used buffering agents, that are recommended for use with different types of detectors.
The Chromatographic Society 2025 Martin and Jubilee Award Winners
December 6th 2024The Chromatographic Society (ChromSoc) has announced the winners of the Martin Medal and the Silver Jubilee Medal for 2025. Professor Bogusław Buszewski of Nicolaus Copernicus University in Torun, Poland, has been awarded the prestigious Martin Medal, and the 2025 Silver Jubilee Medal has been awarded to Elia Psillakis of the Technical University of Crete in Greece.
