LC-MS in Bioanalytical and Biomedical Applications
Di Jiang of the University of Connecticut will kick off this session with a talk on direct liquid chromatography–tandem mass spectrometry (LC–MS/MS) detection of guanine oxidations in a tumor suppression gene.
Session 1790
Room 208C
8:30-11:25 a.m.
Di Jiang of the University of Connecticut will kick off this session with a talk on direct liquid chromatography–tandem mass spectrometry (LC–MS/MS) detection of guanine oxidations in a tumor suppression gene. Next, Ke Li of Missouri University of Science and Technology will discuss the characterization of antibody-drug conjugates in plasma by high resolution time of flight MS. Fangxu Sun of Georgia Tech University will then give a presentation on the analysis of secreted N-glycoproteins in human cells using click chemistry–based enrichment and MS. Zhou Ting of South China University of Technology will then discuss the quantification of inflammation-related lipids in ischemic stroke rates using background subtracting calibration curves with LC–MS/MS.
After the break, Alec C. Valenta of the University of Michigan will present on in vivo neurochemical monitoring using LC–MS, followed by a talk from Yadi Wang of the University of Texas at Arlington on a rapid, sensitive LC–MS/MS method for the quantitation of D-amino acids in mouse brain tissue. Next, Casey Burton of the Phelps County Regional Medical Center in Missouri will present an LC–MS/MS method for the simultaneous determination of 10 putative biomarkers for traumatic brain injury in urine.
Yiyang Zhou of Purdue University will close the session with a talk on improving HPLC resolution and increasing MS compatibility with a novel polymerized bonded phase on silica. The phase was designed to minimize or avoid the need for TFA while also increasing chromatographic resolution compared with conventional alkylsilane bonded phases.
Best of the Week: Food Analysis, Chemical Migration in Plastic Bottles, STEM Researcher of the Year
December 20th 2024Top articles published this week include the launch of our “From Lab to Table” content series, a Q&A interview about using liquid chromatography–high-resolution mass spectrometry (LC–HRMS) to assess chemical hazards in plastic bottles, and a piece recognizing Brett Paull for being named Tasmanian STEM Researcher of the Year.
Using LC-MS/MS to Measure Testosterone in Dried Blood Spots
December 19th 2024Testosterone measurements are typically performed using serum or plasma, but this presents several logistical challenges, especially for sample collection, storage, and transport. In a recently published article, Yehudah Gruenstein of the University of Miami explored key insights gained from dried blood spot assay validation for testosterone measurement.
Determination of Pharmaceuticals by Capillary HPLC-MS/MS (Dec 2024)
December 19th 2024This application note demonstrates the use of a compact portable capillary liquid chromatograph, the Axcend Focus LC, coupled to an Agilent Ultivo triple quadrupole mass spectrometer for quantitative analysis of pharmaceutical drugs in model aqueous samples.
