HPLC 2013, June 16th-20th, Booth E18
DryLab 4 is the next generation UHPLC modeling software. With its comprehensive resolution and robustness mapping abilities, DryLab 4 offers an intuitive and visual solution for method development, optimization, trouble-shooting, robustness testing, and training.
DryLab 4 is the next generation (U)HPLC modeling software. With its comprehensive resolution and robustness mapping abilities, DryLab 4 offers an intuitive and visual software solution for method development, optimization, trouble-shooting, robustness testing, and training. DryLab 4’s 3D modeling capabilities and its multifactorial evaluation of flow rate, column dimensions, instrument parameters, and eluent composition in gradient and isocratic work, provide users with the tools to easily conform to Quality by Design standards. A further robustness evaluation helps users to find the robustness thresholds of their method, and determines which parameters exert the most influence on the critical resolution.
Our latest DryLab 4 feature, the Knowledge Management reporting tool, generates a complete method report, including the Design of Experiments, the 3D model, the robustness calculations, the comparison in retention times between the experimental and predicted outcomes, and all justifications for the method choices. This software tool encourages users to follows a QbD approach to method development, and helps ensure that the completed method conforms to these standards.
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The Complexity of Oligonucleotide Separations
January 9th 2025Peter Pellegrinelli, Applications Specialist at Advanced Materials Technology (AMT) explains the complexity of oligonucleotide separations due to the unique chemical properties of these molecules. Issues such as varying length, sequence complexity, and hydrophilic-hydrophobic characteristics make efficient separations difficult. Separation scientists are addressing these challenges by modifying mobile phase compositions, using varying ion-pairing reagents, and exploring alternative separation modes like HILIC and ion-exchange chromatography. Due to these complexities, AMT has introduced the HALO® OLIGO column, which offers high-resolution, fast separations through its innovative Fused-Core® technology and high pH stability. Alongside explaining the new column, Peter looks to the future of these separations and what is next to come.
Metabolomics Analysis of Low Birth-Weight Infants Using UHPLC-MS/MS Following Lipid Emulsion
January 10th 2025A recent study aimed to directly compare the changes in serum metabolites among very low birth-rate (VLBW) infants following the administration of the soybean oil-based lipid emulsion and soybean oil, medium-chain triglycerides, olive oil, and fish oil (SMOF) lipid emulsion using untargeted metabolomics techniques.
PFAS Analysis in Practice: A RAFA 2024 Interview with Stefan van Leuwen
January 10th 2025At the Recent Advances in Food Analysis (RAFA) conference in 2024, LCGC International sat down with Stefan van Leuwen of Wageningen Food Safety Research to discuss his research, which addresses emerging challenges in circular food production, focusing on the risks posed by pollutants when waste and by-products are repurposed in food systems.
