High-Pressure IC Systems and Columns
High-pressure capillary ion chromatography systems enable use of 4 µm particle-size columns for high-efficiency separations. Choose your optimum balance between fast analysis and high resolution.
High-pressure capillary ion chromatography systems enable use of 4 µm particle-size columns for high-efficiency separations. Choose the optimum balance between fast analysis at higher flow rates and high resolution at standard flow rates. Capillary Reagent-Free™ HPIC™ systems enable 24/7 operation with high reproducibility and system stability, reducing calibration and equilibration time and letting you focus on analysis. Conductivity, electrochemical, and new charge detection options give you the flexibility to apply the power of high-pressure capillary IC to numerous applications. Choose between the integrated Dionex ICS-4000 system for routine capillary HPIC applications, and the modular Dionex ICS-5000 for adaptability and more advanced applications such as two-dimensional IC.
Click to learn more about HPIC systems and applications or email analyze@thermofisher.com
The Complexity of Oligonucleotide Separations
January 9th 2025Peter Pellegrinelli, Applications Specialist at Advanced Materials Technology (AMT) explains the complexity of oligonucleotide separations due to the unique chemical properties of these molecules. Issues such as varying length, sequence complexity, and hydrophilic-hydrophobic characteristics make efficient separations difficult. Separation scientists are addressing these challenges by modifying mobile phase compositions, using varying ion-pairing reagents, and exploring alternative separation modes like HILIC and ion-exchange chromatography. Due to these complexities, AMT has introduced the HALO® OLIGO column, which offers high-resolution, fast separations through its innovative Fused-Core® technology and high pH stability. Alongside explaining the new column, Peter looks to the future of these separations and what is next to come.
Metabolomics Analysis of Low Birth-Weight Infants Using UHPLC-MS/MS Following Lipid Emulsion
January 10th 2025A recent study aimed to directly compare the changes in serum metabolites among very low birth-rate (VLBW) infants following the administration of the soybean oil-based lipid emulsion and soybean oil, medium-chain triglycerides, olive oil, and fish oil (SMOF) lipid emulsion using untargeted metabolomics techniques.
Analyzing New Drug Modalities: An ISC 2024 Interview with Kelly Zhang
January 10th 2025At ISC 2024 in Liverpool, United Kingdom, LCGC International interviewed Kelly Zhang of Genentech about her work analyzing new drug modalities, such as mRNA, oligonucleotides, peptides, and cell and gene therapies.
