Tuesday morning and afternoon presentations taking place in the Daffodil Room highlight the use of GC–MS for analysis of multiple constituents in hydrocarbons, as well as a workshop for the use of pyrolysis in GC and GC–MS.
Tuesday morning and afternoon presentations taking place in the Daffodil Room highlight the use of GC–MS for analysis of multiple constituents in hydrocarbons, as well as a workshop for the use of pyrolysis in GC and GC–MS.
At 10:35 am the session begins with “Analysis of Acrylic Adhesives Using Pyrolysis-GC–MS,” presented by Itsuko Iwai of Frontier Laboratories, Terry Ramus of Diablo Analytical, and Rojin Belganeh, and Robert Freeman of Frontier Laboratories. This presentation provides a method for direct quantitative and qualitative analysis of acrylic adhesives applied to backing (or dicing) tapes used during silicon wafer dicing. Multi-mode Pyrolysis GC–MS was applied for direct analysis of adhesive composition without the requirement of sample preparation. The method described is useful for compositional analysis directly from the adhesive sample.
At 1:00 pm the session continues with “Novel Quantitation Method Development for Asphaltene Inhibitor Analysis Using Pyrolysis GC–MS and MS/MS,” presented by Lei (Lyla) Cheng, Tim Bonner, Christopher Durnell, and Casado-Rivera Emerilis of Ecolab. An optimized pyrolysis GC-MS (selected ion monitoring, SIM) technique has been under development for higher sensitivity quantitative analysis and MRM (multiple reaction monitoring) of asphaltene inhibitors (AI). AIs are polymeric additives used to prevent asphaltene aggregation, which will shift the onset pressure of asphaltenes in processing situations. This new method is promising and requires a small sample of less than 0.2 mg, while demonstrating a linear calibration curve from concentrations of 100 ppm up to 1000 ppm. The method is reported to exhibit high sensitivity and repeatability.
The session closes at 1:20 pm–3:20 pm with the “The Pyrolysis Workshop,” presented by Terry Ramus of Diablo Analytical, with Itsuko Iwai, and Rojin Belganeh of Frontier Laboratories.
The two-hour workshop is planned to cover the basics of GC and GC–MS pyrolysis techniques. The methods described are useful for analysis of organic materials such as solids or viscous liquids or pastes. Methods covered in this course include: pyrolysis, evolved gas analysis, heart-cutting, and thermal desorption. Main topics include materials characterization, deformulation, quantitative methods, data analysis, use of MS library searching, and instrument maintenance. Samples discussed include: biomass, polymers, coatings, additives, and oil shale. The presenters describe this course as suitable for novices to advanced practitioners.
Best of the Week: Food Analysis, Chemical Migration in Plastic Bottles, STEM Researcher of the Year
December 20th 2024Top articles published this week include the launch of our “From Lab to Table” content series, a Q&A interview about using liquid chromatography–high-resolution mass spectrometry (LC–HRMS) to assess chemical hazards in plastic bottles, and a piece recognizing Brett Paull for being named Tasmanian STEM Researcher of the Year.
Using LC-MS/MS to Measure Testosterone in Dried Blood Spots
December 19th 2024Testosterone measurements are typically performed using serum or plasma, but this presents several logistical challenges, especially for sample collection, storage, and transport. In a recently published article, Yehudah Gruenstein of the University of Miami explored key insights gained from dried blood spot assay validation for testosterone measurement.
Determination of Pharmaceuticals by Capillary HPLC-MS/MS (Dec 2024)
December 19th 2024This application note demonstrates the use of a compact portable capillary liquid chromatograph, the Axcend Focus LC, coupled to an Agilent Ultivo triple quadrupole mass spectrometer for quantitative analysis of pharmaceutical drugs in model aqueous samples.