An essential separations technique for your laboratory
The ACQUITY UPC2 System utilizes a powerful new analytical technique, convergence chromatography, giving you reliability, robustness, selectivity, and throughput never before thought possible. With UPC2 Technology, you?ll change the way you address chromatographic challenges.
An essential separations technique for your laboratory
UltraPerformance Convergence Chromatography™ (UPC2®) is a broad-based, complementary analytical platform that is taking its place alongside of LC and GC as one of the three essential separation technologies for modern laboratory analysis.
Orthogonality you can rely on
The ACQUITY UPC2™ System should be your go-to technology platform that can routinely provide reliable orthogonal data. Impurity, degradation peaks, or structurally similar compounds may often be overlooked during analysis. Orthogonal methods that provide different elution orders of peaks are needed to ensure full characterization. Adopt UPC2 into your laboratory, and you’ll experience a faster, more reliable route to orthogonal separations to LC and GC.
Simplified workflow
Because UPC2 can receive samples in organic solvents, it significantly simplifies the requirements for sample preparation, while maintaining all the advantages of RPLC.
With the ACQUITY UPC2 System, the impact on workflow starts with the time saved in sample preparation; add in the time saved in analysis and data interpretation, and you have a complete measurement for a faster route to answers.
The ACQUITY UPC2 System utilizes a powerful new analytical technique, convergence chromatography, giving you reliability, robustness, selectivity, and throughput never before thought possible. With UPC2 Technology, you’ll change the way you address chromatographic challenges.
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The Complexity of Oligonucleotide Separations
January 9th 2025Peter Pellegrinelli, Applications Specialist at Advanced Materials Technology (AMT) explains the complexity of oligonucleotide separations due to the unique chemical properties of these molecules. Issues such as varying length, sequence complexity, and hydrophilic-hydrophobic characteristics make efficient separations difficult. Separation scientists are addressing these challenges by modifying mobile phase compositions, using varying ion-pairing reagents, and exploring alternative separation modes like HILIC and ion-exchange chromatography. Due to these complexities, AMT has introduced the HALO® OLIGO column, which offers high-resolution, fast separations through its innovative Fused-Core® technology and high pH stability. Alongside explaining the new column, Peter looks to the future of these separations and what is next to come.
