Equipment Roundup: New Products Announced from MOBILion Systems, Agilent

In the “Equipment Roundup,” the editors of LC International highlight the newest products from instrument manufacturers around the world. Do you have a new product that you’d like featured in a future installment of LC International’s Equipment Roundup? Send a summary and photo of the product to John Chasse, Managing Editor of LC International, at jchasse@mjhlifesciences.com

MOBILion Systems Unveils Novel High Resolution Mass Spectrometry Functionality

MOBILion Systems announced this week (1) a new approach in complex sample analysis, Parallel Accumulation with Mobility Aligned Fragmentation (PAMAF), delivering speed, sensitivity, specificity and quantitative accuracy for proteomics, lipidomics, and metabolomics workflows.

In a white paper (2), the company said harnessing the capabilities of its proprietary structures for lossless ion manipulation (SLIM)-based high-resolution ion mobility (HRIM) technology enables fragmentation analysis at higher speeds, increasing throughput fivefold, detecting low-abundance signals with near 100% ion utilization efficiency, and providing unmatched precision in the identification of complex biomolecules.

Melissa Sherman, CEO of MOBILion Systems, describes PAMAF as a pivotal development for the company. “Replacing slow, inefficient, lossy quadrupole isolation with high-resolution mobility separation provides unmatched speed and peak capacity and represents a paradigm shift in mass spectrometry, one that will redefine the industry for decades to come and open doors to untold scientific discoveries across countless disciplines,” she said.

PAMAF enables simultaneous processing of all precursors without sacrificing sensitivity inherent to traditional quadrupole isolation. Additionally, by eliminating the traditional quadrupole filter, PAMAF enables the analysis of more samples in less time, the detection of low-abundance signals within complex samples, and reduced ambiguity (resulting in increased confidence with findings)over conventional approaches.

Agilent Announces Release of InfinityLab LC Series Portfolio

Agilent Technologies has announced the release of its next generation Agilent InfinityLab LC Series portfolio, which includes the 1290 Infinity III LC, 1260 Infinity III Prime LC, and 1260 Infinity III LC systems, all including the biocompatible versions. Agilent states that these are the first high-performance liquid chromatography (HPLC) systems on the market to feature the new Agilent InfinityLab Assist Technology, offering enhanced, built-in system assistance capabilities.

The company reported in a press release (3) that the incorporation of the new InfinityLab Assist is designed to enhance the on-board capabilities of the LC for all users. It supports analysts of all skill levels by automating instrument routines, simplifying sample preparation, assisting with maintenance and troubleshooting, and providing context-sensitive help content and solvent management guidance. These features help to eliminate repetitive and error-prone manual tasks, reducing the time required for training and onboarding, and delivering greater robustness and instrument insights that strengthen confidence in the results.

Agilent states that these systems enhance task automation, connectivity, predictive feedback, and error reduction. The innovative built-in sample tracking, utilizing barcoding and camera technologies ensures the elimination of sample mix-ups, providing users with greater accuracy.

REFERENCES

1. “MOBILion Systems Unveils Novel High Resolution Mass Spectrometry

Functionality Representing a Paradigm Shift in Speed and Sensitivity

for Proteomics Workflows.” MOBILion Press release. https://www.prnewswire.com/news-releases/mobilion-systems-unveils-novel-high-resolution-mass-spectrometry-functionality-representing-a-paradigm-shift-in-speed-and-sensitivity-for-proteomics-workflows-302281891.html (accessed 2024-10-21)

2. White paper. https://www.mobilionsystems.com/resources/abandoning-the-quadrupole-for-mass-spectrometry-fragmentation-analysis (accessed 2024-10-21)

3. Agilent Revolutionizes HPLC with the Launch of the Agilent Infinity III LC Series. Agilent press release. https://www.agilent.com/about/newsroom/presrel/2024/21oct-ca24026.html (accessed 2024-10-21)

Concept illustrating the development of a new product in a business context. © Orxan- stock.adobe.com