Emerging Drugs, Tests, and Analyses in the Toxicology Field
This Tuesday morning workshop will feature several discussions involving LC?MS-MS that will be of interest to our readers.
Session 810
Room 409, 8:00 a.m.
This Tuesday morning workshop will feature several discussions involving LC–MS-MS that will be of interest to our readers.
This workshop was organized by Kory Kelly of Phenomenex (Torrance, California) and Borislav Starcevic of the University of California (Los Angeles, California). The workshop will begin with opening remarks from Kelly and continue with a presentation by Les Edinboro (Quest Diagnostics) on tricks and traps when applying LC–MS-MS to clinical toxicology.
The next presentation, "A Streamlined Method for Drugs of Abuse from Urine Using LC–MS-MS that Significantly Reduces Cost per Sample" will be given by Sky Countryman of Phenomenex. Following this will be a presentation from William Ofsa of NMS Labs. Ofsa's talk will focus on using mass spectrometry in a variety of drug analyses.
After a short recess, the workshop will continue with Borislav Starcevic's discussion, "Solving hCG Issues in Doping Control by LC–MS-MS." Charles Kazarian of Navy Drug Screening Laboratories will give the next presentation titled, "Spice: Unravelling the Mystery."
The last presentation in this workshop will be given by Frank W. Crow of the Mayo Clinic who will address causes, evaluation, solutions, and monitoring of ion/matrix suppression in LC–MS-MS. The session will conclude with a brief discussion and wrap-up.
The Complexity of Oligonucleotide Separations
January 9th 2025Peter Pellegrinelli, Applications Specialist at Advanced Materials Technology (AMT) explains the complexity of oligonucleotide separations due to the unique chemical properties of these molecules. Issues such as varying length, sequence complexity, and hydrophilic-hydrophobic characteristics make efficient separations difficult. Separation scientists are addressing these challenges by modifying mobile phase compositions, using varying ion-pairing reagents, and exploring alternative separation modes like HILIC and ion-exchange chromatography. Due to these complexities, AMT has introduced the HALO® OLIGO column, which offers high-resolution, fast separations through its innovative Fused-Core® technology and high pH stability. Alongside explaining the new column, Peter looks to the future of these separations and what is next to come.
Metabolomics Analysis of Low Birth-Weight Infants Using UHPLC-MS/MS Following Lipid Emulsion
January 10th 2025A recent study aimed to directly compare the changes in serum metabolites among very low birth-rate (VLBW) infants following the administration of the soybean oil-based lipid emulsion and soybean oil, medium-chain triglycerides, olive oil, and fish oil (SMOF) lipid emulsion using untargeted metabolomics techniques.
Analyzing New Drug Modalities: An ISC 2024 Interview with Kelly Zhang
January 10th 2025At ISC 2024 in Liverpool, United Kingdom, LCGC International interviewed Kelly Zhang of Genentech about her work analyzing new drug modalities, such as mRNA, oligonucleotides, peptides, and cell and gene therapies.
