Does Optimization in the Manufacturing Process of An Established CSP Make a Difference in Chiral Separations
A Performance Comparison of Whelk-O 1 Bonded to Exsil and Kromasil Silicas.
Innovation and new applications in chiral chromatography for the pharmaceutical, chemical and agricultural industries are essential to success in this highly competitive market. A key component of a chiral column is the starting silica used to bond the stationary phase. Although suppliers make claims of superiority about the silica used, real-life data can lead to different conclusions and can impact analytical and preparative separations.
Described here is a head-to-head comparison of ten well-characterized chiral reference compounds run by HPLC and SFC on 5 μ Whelk-O 1 phases bonded to two silica particle types; Exsil and Kromasil, which are both spherical uniform porous silica particles.
Modern HPLC Strategies: Improving Retention and Peak Shape for Basic Analytes
August 16th 2024In high-performance liquid chromatography (HPLC), it is common for bases and unreacted ionized silanols on silica-based columns to cause irreproducible retention, broad peaks, and peak tailing when working with basic analytes. David S. Bell, Lead Consultant at ASKkPrime LLC offers innovative HPLC strategies that can help mitigate such issues.
Characterizing Cooked Cheese Flavor with Gas Chromatography
September 19th 2024A joint study by the Department of Food and Nutritional Sciences at the University of Reading and Synergy Flavours aimed to identify volatiles that contribute to the aroma of cooked cheese, including the role of fat content in development during cooking.
