Best of the Week: Next Generation Peak Fitting, AI in Analytical Chemistry
This week, LCGC International published a variety of articles on the hottest topics in chromatography and beyond. Below, we’ve highlighted some of the most popular articles, according to our readers. Happy reading!
Next Generation Peak Fitting for Separations
M. Farooq Wahab, Troy T. Handlovic
Real-world chromatographic separation often have difficult critical pairs that can fail to resolve under most experimental conditions. Standard advice in such instances is to employ a different column chemistry, design a better gradient, or select a different mobile phase system. Screening conditions to produce a chromatogram without peak overlap consumes costly time and solvents in a busy laboratory. To save time and expensive solvents, an effective alternative to conventional screening protocols or mathematical peak width reduction is called iterative curve fitting. This method does not sharpen the peaks to enhance the chromatographic resolution, but extracts the original shape from overlapping peaks in a complex separation, as if an isolated compound were injected. With this protocol, the profile of each peak, overlapping or non-overlapping, is obtained as if a single component were injected instead of a mixture.
Revolutionizing the World of Analytical Chemistry: The AI Breakthrough
Jerome Workman, Jr.
Artificial intelligence (AI) has emerged as a transformative force across various scientific fields. In analytical chemistry, AI is revolutionizing the approach to complex data analysis and the development of innovative methods for separation science and spectroscopy. AI is being applied for rapid spectroscopic food analysis, surface-enhanced Raman spectroscopy, metabolite profiling using nuclear magnetic resonance (NMR) spectroscopy, and many other applications. A recent review by Rafael Cardoso Rial of the Federal Institute of Mato Grosso do Sul in Brazil explores this topic with 134 references in the journal Talanta.
Celebrating Roy Lautamo: A “Giant” of GC Column Technology Development
Jerome Workman, Jr.
It is with profound sadness that the editorial staff at LCGC International announce the passing of Roy Lautamo, a cherished friend and esteemed developer of gas chromatography column technology, who succumbed to a heroic battle with thyroid cancer on May 13, 2024. Lautamo was 70 years old. For those fortunate enough to have worked with Lautamo and those who never had the pleasure, he was a genius in the gas chromatography (GC) industry, responsible for numerous technical advancements. Here, we remember his storied career and accomplishments.
Inside the Laboratory: Grinias Research Lab at Rowan University, Part IV – Advice from Students
Patrick Lavery
Rowan University in Glassboro, New Jersey, is home to the Grinias Research Lab headed by James Grinias, a professor in the department of Chemistry & Biochemistry. In this final installment of our miniseries on the Grinias Research Lab, In the video below, graduate students Leah Notarfrancesco, John Boughton, and Christopher Piccolo share tips and insight for the next generation of aspiring separation scientists. This concludes LCGC's visit to Rowan, with more hopefully to follow in the future at other academic institutions.
Reviewing Environmental Applications of Miniaturized Liquid Chromatography Systems
Aaron Acevedo
Thanks to work conducted in industry and academia, miniaturized liquid chromatography (LC) has evolved in various ways since its inception. The first commercialized miniaturized LC products launched in 1987. Since then, small LC systems have become indispensable tools for bioanalytical research. The miniaturization of LC is generally done to increase sensitivity, which is necessary in proteomics to detect low abundant peptides and proteins; other benefits can include improving the efficiency of interfacing with mass spectrometry and the reduction of solvent consumption. This technique is even more important with the widespread use of chemicals, which discharge into the environment and can be hazardous to human health, even at low concentrations.
The Future of Digital Method Development: An Interview with Anne Marie Smith
September 5th 2024Following the HPLC 2024 Conference in Denver, Colorado, LCGC International spoke with Anne Marie Smith of ACD/Labs about the new ICH Q14 guidelines and how they impact analytical scientists and their work.
Analytical Challenges in Measuring Migration from Food Contact Materials
November 2nd 2015Food contact materials contain low molecular weight additives and processing aids which can migrate into foods leading to trace levels of contamination. Food safety is ensured through regulations, comprising compositional controls and migration limits, which present a significant analytical challenge to the food industry to ensure compliance and demonstrate due diligence. Of the various analytical approaches, LC-MS/MS has proved to be an essential tool in monitoring migration of target compounds into foods, and more sophisticated approaches such as LC-high resolution MS (Orbitrap) are being increasingly used for untargeted analysis to monitor non-intentionally added substances. This podcast will provide an overview to this area, illustrated with various applications showing current approaches being employed.
Nanospray Laser-Induced Plasma Ionization Mass Spectrometry to Analyze Persistent Organic Pollutants
September 3rd 2024Scientists from the Guangdong Academy of Sciences and the Guangdong University of Technology used nanospray laser-induced plasma ionization mass spectrometry (nLIPI-MS) to analyze broad polarity organic pollutants under ambient and open-air conditions.
