ASMS 2023: A Look at the Tuesday Morning Oral Session on Exposomics, Toxicology, and Health Outcomes

From 8:30–10:30 a.m., there was an oral session titled “Exposomics, Toxicology, and Health Outcomes” which took place in Room 332. The session, chaired and presided over by Yinsheng Wang of the University of California, Riverside, included six talks about the use of mass spectrometry in determining health outcomes, including those brought about by surgeries or environmental issues.

To begin the session at 8:30 a.m., Benedikt Warth of the University of Vienna in Vienna, Austria took a look at the “chemical exposome” of food- and environment-related molecules humans encounter that may impact the etiology of a large share of diseases, and the next-generation approaches to biomonitoring that are being developed.

Next, at 8:50 a.m., Haoqi Nina Zhao of the University of California San Diego in San Diego, California, USA discussed how a tandem mass spectrometry (MS/MS) “library” of drugs and metabolites, propagated from repository-scale molecular networking, facilitated medication read-out in untargeted metabolomics.

The third talk of the session, at 9:10 a.m., was given by Kevin Murray of the Masonic Cancer Center at the University of Minnesota in Minneapolis, Minnesota, USA, and focused on the development of a sensitive, high-resolution method of liquid chromatography coupled to tandem mass spectrometry (LC–MS/MS) for the profiling of mercapturic acid conjugates in urine.

At 9:30 a.m., Joshua Smith of Johns Hopkins University in Baltimore, Maryland, USA talked about the use of Pan-Protein Adductomics (PPA) to detect temporal changes in the serum albumin adductome following bariatric surgery.

Following that, at 9:50 a.m., Pablo Gago Ferrero with the Institute of Environmental Assessment and Water Research of the Spanish Council for Scientific Research in Barcelona, Spain talked about the lack of characterization of the chemical exposome of cancerous brain tumors such as diffuse gliomas.

Finally, at 10:10 a.m., Rebecca Beres of the University of North Carolina at Chapel Hill in Chapel Hill, North Carolina, USA assessed per- and polyfluoroalkyl substances (PFAS) and lipidic alterations in plants grown in contaminated soil.