ACQUITY QDa Detector
The ACQUITY QDa Detector is the mass detector designed as a synergistic element of your chromatographic separations systems. It is mass detection built around the needs of your analytical scientists for their chromatographic analysis.
Imagine a lab where all analytical scientists can acquire high-quality mass spectral data. On their own. Within their existing workflow. Across every sample. Without training. A lab where uncertainty about compounds is replaced by fast, efficient confirmation and the confidence that comes with crossing the LC/MS divide like never before. Now imagine all this happening at the push of a button. This goes far beyond the power of mass detection. This is the ACQUITY® QDaTM Detector from Waters.
Working in harmony with your chromatography, it is pre-optimized to work with your samples, without the sample-specific or user adjustments typical of traditional mass spectrometers. For the first time, any analytical scientist can consistently generate the highest quality mass spectral data, routinely without the need for any special training or expertise thus eliminating any need to contract out and wait for results from specialist analytical service laboratories.
Having the mass spectral information you need, for the analytical confidence you demand, was beyond the reach of most. Until now. This is certainty above all else. This is SEPARATING BEYOND QUESTIONTM.
Website: www.waters.com
The Complexity of Oligonucleotide Separations
January 9th 2025Peter Pellegrinelli, Applications Specialist at Advanced Materials Technology (AMT) explains the complexity of oligonucleotide separations due to the unique chemical properties of these molecules. Issues such as varying length, sequence complexity, and hydrophilic-hydrophobic characteristics make efficient separations difficult. Separation scientists are addressing these challenges by modifying mobile phase compositions, using varying ion-pairing reagents, and exploring alternative separation modes like HILIC and ion-exchange chromatography. Due to these complexities, AMT has introduced the HALO® OLIGO column, which offers high-resolution, fast separations through its innovative Fused-Core® technology and high pH stability. Alongside explaining the new column, Peter looks to the future of these separations and what is next to come.
Metabolomics Analysis of Low Birth-Weight Infants Using UHPLC-MS/MS Following Lipid Emulsion
January 10th 2025A recent study aimed to directly compare the changes in serum metabolites among very low birth-rate (VLBW) infants following the administration of the soybean oil-based lipid emulsion and soybean oil, medium-chain triglycerides, olive oil, and fish oil (SMOF) lipid emulsion using untargeted metabolomics techniques.
Analyzing New Drug Modalities: An ISC 2024 Interview with Kelly Zhang
January 10th 2025At ISC 2024 in Liverpool, United Kingdom, LCGC International interviewed Kelly Zhang of Genentech about her work analyzing new drug modalities, such as mRNA, oligonucleotides, peptides, and cell and gene therapies.
