May 17th 2024
Here are the top five articles that the editors of LCGC International published this week.
Machine Learning Models Help Researchers Predict the Ages of Ginseng
November 9th 2023To combat fraudulent sales of low-aged ginseng disguised as high-aged ginseng, scientists from Shanghai University of Traditional Chinese Medicine created machine learning models to predict the ages of ginseng samples.
The Evolution of Breath Analysis
November 3rd 2023The Column spoke with Ilaria Belluomo from Imperial College London, UK, about her research in breath analysis. She details her work into a noninvasive breath test that can be used to detect colorectal cancer using GC–MS. She also discusses the use of SIFT-MS for the analysis of VOCs in breath.
Dracula in Print: Ethylene-Vinyl Acetate Technology Aids MS Analysis of Vlad the Impaler’s Letters
October 31st 2023Ethylene-vinyl acetate (EVA) was used in tandem with high-resolution mass spectrometry (HRMS) because it was non-invasive and non-damaging to three letters written in the second half of the 15th century by Vlad III of Wallachia.
Gulf Coast Conference: John Wasson Discusses Data Retrieval From Chemical Processing Plant Streams
October 25th 2023At the 2023 Gulf Coast Conference, LCGC spoke with John Wasson of Wasson-ECE Instrumentation, who discussed the process of retrieving high-quality, real-time data from chemical processing plant streams. This interview was one of four conducted live at GCC 2023.
Spatially Resolved Metabolomics Reveals Tumor-Immune Cell Interactions
October 25th 2023Researchers have developed a 3D tumor-immune cell coculture spheroid model combined with mass spectrometry (MS) imaging-based spatially resolved metabolomics, offering insights into metabolic alterations during antitumor immune responses.
LC and Green Chemistry Advancements in Lenvatinib Stability Testing and Environmental Responsibility
October 23rd 2023A novel lenvatinib stability-indicating method, developed through a quality by design (QbD) approach and embracing principles of green chemistry, offers a robust solution for ensuring the drug's stability under various conditions.
HPLC and LC–MS Estimation of Goserelin Acetate Sustained-Release Implant Impurity
October 21st 2023Researchers have developed a meticulous method for analyzing impurities in a product used for early treatment of breast cancer in premenopausal and perimenopausal women, shedding light on the product’s degradation pathways.
Imaging Mass Spectrometry with Gas-Phase Charge Inversion Ion/Ion Reaction Separates Isobaric Lipids
October 16th 2023Researchers from the University of Florida have employed gas-phase charge inversion ion/ion reactions to distinguish isobaric lipids in imaging mass spectrometry, offering enhanced molecular specificity for analyte identification.
Two IMS-MS Modalities Assist Nonenzymatic Posttranslational Modification Studies Without Mass Loss
October 13th 2023Researchers at two US colleges have utilized ion mobility spectrometry–mass spectrometry (IMS-MS) to analyze nonenzymatic posttranslational modifications and peptide cleavages in a single peptide system, revealing insights into critical biomarkers for age-related diseases.
Q&A: FDA Talks to LCGC About Chromatographic Techniques for PFAS Detection in Food Supply
October 13th 2023FDA scientists have expanded the number of analytes in their analytical method for per- and polyfluoroalkyl substances (PFAS), partly in response to updated guidance out of the European Union (EU) on method parameters and limits of quantification (LOQs).
AIU–IM–MS Unlocks Precision in Assessing Therapeutic Antibody Stability
October 12th 2023Researchers in Tianjin, China, have employed all ion unfolding–ion mobility–mass spectrometry (AIU–IM–MS) to enhance the differentiation of therapeutic polyclonal antibodies, offering insights into improvements in conformational stability and advantages in cost-effectiveness.