Liquid Chromatography (LC/HPLC)

Researchers have developed a multitargeted internal calibration method for precise quantification of chronic kidney disease (CKD)-related endogenous metabolites using liquid chromatography–mass spectrometry (LC–MS).

At the Cannabis Sciences Conference, Zacariah Hildenbrand held a talk which focused on various analytical methods and how they affect the cannabis production process.

Okadaic acid (OA) is considered a marine toxin with distributed hydroxyl, polycyclic ether, and carboxyl groups, easily accumulated in shellfish and known to cause food poisoning in humans.

In a recent study, researchers from China presented a novel approach that uses a supramolecular solvent (SUPRAS) method for detecting bioactive compounds.

This review of pharmaceutical analysis in the last three years includes three categories of chiral liquid chromatography stationary phases: saccharides, macrocyclic substances, and porous organic materials.

Scientists from the National Institute of Pharmaceutical Education and Research (NIPER) in India used a variety of techniques to characterize erdafitinib and its various products.

Researchers from Hebei University in China have developed and characterized three novel peptide chiral stationary phases (CSPs) for enantiomeric separation, demonstrating their potential in high performance liquid chromatography (HPLC).

Researchers from Corteva Agriscience tested a new approach for separating and quantifying small molecule structure elucidation.

A pair of scientists from Gdańsk University of Technology (GUT) in Gdańsk, Poland, used the method to analyze the presence of antibiotics in animal products like milk and eggs.

We spoke with Ibraam Mikhail, a postdoctoral research fellow (analytical chemistry) at the Australian Centre for Research on Separation Science (ACROSS), University of Tasmania, Australia, about his work developing a multiwavelength absorbance detector that uses pulsed-deep ultraviolet light-emitting diodes (DUV-LEDs), and how this detector performs compared to other standard detectors.

Small modifications to the way measurements are approached can enable reductions in the waste generated and carbon dioxide produced during an analysis.

The 27th International Symposium on Separation Sciences (ISSS 2023) will be held 24–27 September 2023 in Cluj-Napoca, Romania. Here’s a sneak preview of what attendees can look forwards to.

Pop quiz—can you define resolution? Would you be surprised at the number of correct answers? Which one is the best for chromatographers? In this LCGC Blog, we look at the various ways resolution can be interpreted scientifically.

Brazilian scientists are testing a system to detect endocrine disruptors in wastewater samples to help improve public health.

Researchers from the University of Washington have begun testing a new system to fight antimicrobial resistance by combining liquid chromatography (LC) with ion mobility (IM) separation.

Optimal reaction conditions for the desired deethylation were found to be mild, using only water and oxygen at or close to ambient temperatures.

The author outlines multiple protective and troubleshooting methods for liquid chromatography and how these approaches have changed over time.

This retrospective focuses on trends and topics that were discussed at the annual HPLC symposium in Duesseldorf, Germany.

The success of screening column and mobile phase combinations that generate dissimilar selectivity is highlighted in a typical method development strategy.

Understanding the relationship between a number of variables and analysis time, and their effects on other choices made during method development, is helpful for developing methods that are both effective and time-efficient.

This instalment of “Column Watch” presents many of the highlighted topics and trends observed at this exceptionally well-run symposium.

The latest developments and challenges of using liquid chromatography (LC) for copolymer analysis are discussed.

Orange Photonics said the agency will use its LightLab 3 as part of a broader effort to regulate and test the safety of food-related cannabis products.

The combination of the “bottom-up” approach with digest-free, direct-sequencing proteomics, along with the addition of a proteogenomics pipeline that identified missing data, yielded the determination of almost 3000 proteins.

A recent review article discussed advances in liquid chromatography (LC) enantioseparations.

Researchers in China studied a new process for measuring aberrant metabolites.

Studies published over the last five years have focused on fully or semi-automated approaches and their applications in extraction of both organic and inorganic pollutants, while modern robotic tools and 3D printing are starting to make impacts.

HRPs, while vital to creating drugs meant to fight serious diseases, are very difficult to quantify. To streamline the process, a group of scientists used a new approach for analyzing HRPs using MSPE and HPLC-UV.

Since similar chiral recognition mechanisms were observed for benzoin (B) and methyl mandelate (MM), a three-site enantioselectivity model was proposed to interpret the data being sought by researchers.

Microfluidic devices are considered ideal for fabricating portable diagnostic equipment for point-of-care testing, but substrates more environmentally friendly than glass or plastics are attracting interest.