Duodenal mucosal resurfacing (DMR), a new-style endoscopic procedure using hydrothermal energy to ablate this thickened layer, shows promise for enhancing glucose and lipid metabolism in type 2 diabetes patients. However, the mechanisms driving these improvements remain largely unexplored. Researchers investigated the mechanisms by which DMR improves metabolic disorders using a rat model. Gut microbiota and metabolomics profiles were analyzed through 16S rRNA gene sequencing and ultrahigh pressure liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS).

Flavonoids are widely used metabolites that carry out various functions in different industries, such as food and cosmetics. Detecting, separating, and quantifying them in fruit species can be a complicated process.

Highly reactive aldehydes can pose significant health concerns in polluted environments. HPLC was used in this study to simultaneously analyze carbonyl compounds hydrazones.

A recent study conducted at the University of Georgia, (Athens, Georgia) presented a validated method for quantifying 18 terpenes in Cannabis sativa essential oil, extracted via hydrodistillation. The method, utilizing gas chromatography–mass spectrometry (GC–MS) with selected ion monitoring (SIM), includes using internal standards (n-tridecane and octadecane) for accurate analysis, with key validation parameters—such as specificity, accuracy, precision, and detection limits—thoroughly assessed. LCGC International spoke to Noelle Joy of the University of Georgia, corresponding author of this paper discussing the method, about its creation and benefits it offers the analytical community.

Shimadzu researchers aimed to develop a more efficient supercritical fluid chromatography method for solid-state injection and streamlining sample pretreatment.

Here is some of the most popular content posted on LCGC International this week.

Green analytical chemistry is no longer a niche concept but a necessity in today’s environmentally conscious world.

We spoke with Josh Hoerner, general manager of Purisys, which specializes in a small volume custom synthesis and specialized controlled substance manufacturing, to gain his perspective on FDA’s recommendations for acceptable intake limits for N-nitrosamine impurities.

A new collaboration facility, opened by Thermo Fisher Scientific, will work to make cell therapy developers’ research more accessible and optimized.

The critical role of separation science in per- and polyfluoroalkyl substances (PFAS) research highlights just how essential chromatography is in solving complex challenges that benefit society.

Texas Tech University researchers used liquid chromatography–tandem mass spectrometry to quantify glucose transporter 1 (GLUT1) in mammalian brain cells.

Root exudates—substances secreted by living plant roots—are challenging to sample, as they are typically extracted using artificial devices and can vary widely in both quantity and composition across plant species.

Researchers used liquid chromatography–mass spectrometry (LC–MS) in their proteomic analysis to compare the serum proteome of migraine patients with healthy controls and to identify differentially expressed proteins as potential migraine biomarkers.

Imre Molnár, president of the Molnár-Institute for Applied Chromatography, will be presented with the Tswiett-Nernst European Award at the ISSS conference in September 2025.

A new study, published by a researcher from Chemical Characterization Solutions in Minnesota, explored a new approach for sample preparation for the chemical characterization of medical devices.