Antec — Proven Performance

Antec introduces a new product line, named ROXY™, for on-line Electrochemistry/MS. The line consists of the following 3 major products:
(i) ROXY™ Potentiostat, (ii) ROXY™ EC system and (iii) ROXY™ EC/LC system and brings Electrochemistry (EC) to the fingertips of all Mass Spectrometrists.

The ROXY™ Potentiostat is the ideal tool for studying Redox reactions of single compounds. It generates metabolites of drugs or xenobiotics, similar to those generated during in vivo metabolic processes, in a significantly shorter time span (seconds vs. days or weeks) without any interfering components (no isolation steps required). The ROXY™ Potentiostat is based on state-of-the-art electronics with a large voltage range of ± 4.9 V. Operational parameters can be controlled automatically through programmable timed events. Consequently, the generation of specific oxidation products (e.g., metabolites, cleavage products, etc.,) and supreme control of any conceivable Redox reaction is assured.

The ROXY™ EC system is the ideal introduction device for Electrospray Ionization (ESI)-MS. The system consists of a dual syringe infusion pump and the Potentiostat. For known compounds (e.g., drug candidates, pollutants, pesticides, etc.,) a quick profiling and/or reconfirmation of potential metabolites is often sufficient for decision making. Therefore, target compounds can be directly infused through the electrochemical ReactorCell into the MS, often without the need of any liquid chromatographic separation (HPLC), making EC/MS a very powerful tool for fast metabolic profiling and related applications. The resulting time and cost savings are substantial when compared with daunting in vivo or in vitro experiments.

With the introduction of the ROXY™ EC/LC system, on-line EC/LC/MS for automated screening of numerous samples becomes available for the first time.The system is based on a dedicated binary high pressure gradient pump with implemented ReactorCell as part of the fluidic pathway. Furthermore specifically designed liquid handling programs allow for the addition of reagents, making Phase II reactions (i.e., adduct formation) in drug/xenobiotic metabolism easy accessible. Other applications include the studies of covalent drug-protein binding, mimicking oxidative damage of proteins, DNA, etc., or the studies of reagents, (e.g., antioxidants,) on biopolymers and their biotransformation.

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