Application Notes: General

A QuEChERs + SPE sample preparation technique coupled with LC–MS/MS is shown to provide sub-ppb analysis of PFAS in dairy and fish samples.

Validation of a water and wastewater method for the California PFAS panel using SPE (WAX/GCB) preparation and LC–MS/MS analysis with a variable pH LC mobile phase

Phenomenex announces a new graphitized carbob black (GCB) SPE tube for DOD QSM 5.3 compliant PFAS analysis.

A municipal wastewater laboratory demonstrates the use of QuEChERs sample preparation techniques to analyze PFAS in sediments at sub ng/g levels.

A municipal wastewater laboratory demonstrates the use of QuEChERs sample preparation techniques to analyze PFAS in sediments at sub ng/g levels.

A wide variety of LC column chemistries were evaluated to demonstrate new chromatographic approaches to complex PFAS analyte lists.

Strata-SDB-L and Luna Omega 1.6 µm PS C18 demonstrate excellent precision and recovery in EPA Method 537.1 for the analysis of PFAS in drinking water.

A novel LC approach to manipulate the chromatography of closely related PFAS analytes to separate co-eluties and avoid matrix interferences.

3-MCPD and glycidyl fatty acid esters are processing-induced contaminants of concern, primarily found in refined fats and oils, and foods derived from them.

An online thermal desorber has been developed for the automated, in situ, determination of VOCs. The system does not need liquid nitrogen or CO2.

Plasticizers added to water bottles to add stability to the bottles can be unknowingly extracted in drinks leading to possible endocrine interactions. 

This application note outlines the analysis of PFAS in drinking water according to EPA 533 using UCT’s Enviro-Clean® polymeric weak-anion exchange (WAX)SPE cartridges. 

AAV characterization and stability screening are achieved with multi-angle light scattering coupled to separation methods and high-throughput dynamic light scattering.

In this application note, a method for extracting a large drugs of abuse panel from urine and plasma using UCT’s Micro-Prep® HLB microelution plate has been described.

To demonstrate fast, highly sensitive quantitation of nine nitrosamines with LC–MS measuring impurities in commercially available ranitidine drug substances and products

This application note demonstrates robust and sensitive quantitation of 10 nitrosamines, and the use of the LC–SRM–MS to quantify nitrosamine impurities in metformin.

This application note demonstrates fast, highly sensitive quantitation of nine nitrosamines, and the use of the LC–MS method to measure nitrosamine.

Download this guide to learn the strategies to consolidate chemical reference parameters and population biomarker analysis to support the wastewater-based epidemiology.

This article introduces a comprehensive fractionation for both UV absorbing and non-UV absorbing compounds using a newly designed PDA-ELSD triggered preparative LC.  

This e-book demonstrates the use of Purge and Trap coupled with GC–MS to meet the challenges of VOC analysis for the most common EPA regulations and methods.

Multivitamin standards were prepared and filtered using 2-step Verex Filter Vials.

Hydrocortisone was extracted from a topical cream and filtered using Verex Filter Vials. Samples were run by LC–UV to see if using filter vials created any loss of sample.

IgG1 (Trastuzumab) and an IgG4 (Nivolumab) are digested with IdeZ protease, yielding Fab2’ and scFc fragments that were filtered using Verex Filter Vials to determine if there was a loss of sample.

In this application, Methylmalonic Acid (MMA) samples were filtered and tested to determine that no extractables were introduced by using the Verex Filter Vials.

Polychlorinated Biphenyls (PCBs) were prepared and filtered using Verex Filter Vials and traditional syringe filters.

In this application, atorvastatin standards were prepared and filtered using Verex Filter Vials. Samples were analyzed by LC–UV.

Chili powder and cumin powder were analyzed for pesticides and clean-up using Verex Filter Vials to remove undissolved sample particulates.

This application guide provides a comprehensive collection of simple sample preparation applications using filtration.

Get a better understanding of how ion chromatography plays an important role in pharmaceutical research and development.